Healthcare resource utilization among patients with cold agglutinin disease in Denmark

Objectives Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia that may manifest in complement-mediated chronic anemia, profound fatigue, and transient agglutination-mediated circulatory symptoms. This study compared the healthcare resource utilization (HRU) patients with CAD matched non-CAD comparison cohort using national Danish health registry data.Methods All cases were identified from 1 January 1999 to 30 June 2016, National Patient Registry International Classification Diseases, Tenth Revision, discharge diagnosis codes. A subcohort primary was based on absence secondary predisposing concomitant diseases. individuals without general population birth year, sex, 19 categories Charlson Comorbidity Index. Comparative analyses assessed inpatient hospitalizations, outpatient clinic visits, emergency room transfusion use, expensive drug use between cohorts 6 months before 12 after admission date first hospital visit (index date).Results total 104 1003 members. Throughout index date, more likely have at least one hospitalization (odds ratio [OR], 3.9; 95% confidence interval [CI], 2.5–6.0), (OR, 17.2; CI, 6.8–43.1), blood 93.0; 33.3–259.8) than comparisons. HRU similarly higher among comparisons during date. Findings similar CAD.Conclusions Characterization European has not previously been conducted. shows utilize significant resources Denmark. Increased uses presents opportunities for earlier management.